Wound Healing

A wound occurs when there is a break or opening in the skin or mucous membranes. Wound healing is a complex process that starts the moment an injury occurs and can continue for weeks or months There are three stages to wound healing:

Remember that this process is somewhat different in EB because wounds are acute, not chronic in nature. Often, they do not reach the remodeling stage in areas of high friction, because these areas re-blister frequently

During the inflammatory stage, in response to immediate bleeding, the blood vessels narrow (vasoconstriction). Platelets collect in the wounded area (platelet aggregation), and a clot forms with assistance from thromboplastin (clotting factor). Specialized inflammatory cells — neutrophils, macrophages and monocytes — are recruited to the wound site where they ingest cell debris, along with microorganisms, to clean the wound bed.

In the proliferative stage, blood vessels are regrown and skin cells called fibroblasts make collagens, which are important structural skin proteins. The wound edges start to knit together, and there is regrowth of epithelial skin cells (epithelialization).

In the remodeling stage, the new collagen forms a stronger, more formal structure. Epithelialization continues, and the wound is healed.

When wounds are healing slowly or appear not to be healing, the condition of the wound bed should be considered.

The first step is to assess the ability of the wound to heal. Consider these factors:


Treat any infection with the use of topical antibiotics or antimicrobial silver dressings.

Choose dressings that support the healing process. Non-adherent dressings are essential to the wound-healing process in EB. Choose dressings that are appropriate for the type of wound. Continue to monitor the size, location and appearance of the wound, and assess whether the wound looks better or worse. The type of dressing used may need to changed as the wound improves as well as if it does not.

Address nutritional requirements. Make sure caloric intake is appropriate, in particular protein intake. Many children with EB also take vitamin and mineral supplements to aid wound healing, including iron, zinc, and vitamin C.

Treat any associated itching to prevent scratching, which can interfere with wound healing.

If the wound care plan does not improve healing, different treatments may be needed. Your wound care specialist may consider the use of alternative therapies such as specialized biological dressings, including Dermagraft® and Apligraft®.